Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2879-82. doi: 10.1016/s0960-894x(02)00601-7.

Abstract

A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.

MeSH terms

  • Amides / chemical synthesis*
  • Amides / pharmacology*
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / pharmacology
  • Antiviral Agents / toxicity
  • Crystallography, X-Ray
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Enzyme Inhibitors / toxicity
  • Gastrointestinal Diseases / chemically induced
  • Gastrointestinal Diseases / pathology
  • IMP Dehydrogenase / antagonists & inhibitors*
  • Immunosuppressive Agents / chemical synthesis
  • Immunosuppressive Agents / pharmacology
  • Immunosuppressive Agents / toxicity
  • Indicators and Reagents
  • Structure-Activity Relationship

Substances

  • Amides
  • Antiviral Agents
  • Enzyme Inhibitors
  • Immunosuppressive Agents
  • Indicators and Reagents
  • IMP Dehydrogenase